Dictionary![]() ![]() Clay•tonPronunciation: (klāt'n), [key] —n. 1. John Middleton, 1796–1856, U.S. jurist and politician: senator 1829–36, 1845–49, 1853–56; Secretary of State 1849–50. 2. a city in E Missouri, near St. Louis. 14,219. 3. a male given name. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease.
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