Dictionary![]() ![]() San•to To•mé de Gua•ya•naPronunciation: (sän"tô tô-me' &thslash;e gwä-yä'nä), [key] a city in NE Venezuela, on the Orinoco River. 143,540. Also called Ciudad Guayana. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease.
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