Dictionary![]() ![]() de•spairPronunciation: (di-spâr'), [key] —n. 1. loss of hope; hopelessness. 2. someone or something that causes hopelessness: He is the despair of his mother. —v.i. to lose, give up, or be without hope (often fol. by of): to despair of humanity. —v.t. Obs.to give up hope of. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease.
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